The entire upper floor of the Museum is dedicated to wind musical instruments.

The exhibits belong to the typical craftsmanship that developed in Quarna Sotto as early as the 19th century. Instruments made by the companies of Egidio Forni, his nephew Agostino Rampone, I. M. Grassi, and other companies founded by some local artisans have been exported worldwide, including both woodwind and brass instruments. By the end of the 19th century and into the 20th century, a large part of the town's men worked in this company, which had its administrative and commercial headquarters in Milan, as well as part of the manufacturing processes. The exhibition displays various types of wind instruments, but predominantly saxophones, and importantly, many prototypes that were used for the study and design of the key mechanisms.

There are attempts to manufacture instruments with new characteristics, instruments made to order for conservatory and orchestra professors, and outdated instruments such as sarrusophones and saxorussophones. Current production instruments are also displayed, such as the unique Alessofono, an alto saxophone designed by the architects of Alessi Casalinghi and produced by Rampone & Cazzani. The machines and equipment used by workers for the production of metal or wood instruments are also on display, which they modified to achieve the best possible performance. All stages of production are exhibited, culminating in the finished instrument ready for testing. Thus, it is a true exhibition of the history of this traditional craftsmanship.

In summary, these are the characteristics that make the Quarna Museum one of the very few in the world on this topic.